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Resveratrol A to Z

Resveratrol (res-ver-a-trol)

Resveratrol is a type of polyphenol that can be found naturally in a variety of sources including grapes, Japanese knotweed (giant knotweed), berries, peanuts, dark chocolate and tea.

The French Paradox: Resveratrol, a compound found in red wine, first gained publicity in the early nineties when the CBS television show, 60-Minutes, investigated why people living in France, despite eating diets high in saturated fats, had lower rates of coronary heart disease than people living in the United States. The report concluded that a higher consumption of red wine may play a role in lowering coronary heart disease. Since then, researches have pointed to resveratrol, a substance contained in grape skins (and other plants such as Japanese knotweed), as the compound with the possibility of preventing or delaying coronary heart disease and many other health conditions. 

What Should You Know Before Purchasing Resveratrol?

Its not surprising that consumers are confused about resveratrol products. Resveratrol is a general name for a product that is available in various purities: 5%, 10%, 20%, 50%, and 99%.  In principle buying resveratrol is the same as buing gold. Gold is available in different purities and the law requires the dealer to clearly stamp the purity of the gold on the item (e.g. 5 , 9, 14  or 24 karat). If the resveratrol manufacturer does not indicate the purity on the label, then there is no way of knowing the amount of trans-resveratrol in the product, or if it has any health benefits at all. Resveratrol can provide great health benefits ONLY if it contains sufficient amounts of trans-resveratrol, the active ingredient and the beneficial substance in resveratrol.  “resveratrol” does not mean Trans-resveratrol.

It is important to note that most resveratrol sold in USA and abroad is of a low purity (50% or less ).  Since the FDA does not regulate the purity content labeling of dietary supplements, it is not surprising that manufacturers that offer low-purity resveratrol are doing it solely for monetary gain and therefore they do not disclose the purity content of the product. Instead, they use misleading descriptions such as “Extra Strength”, “Super Potency”, “High Purity”, “Pure Resveratrol” and other misleading statements. Remember, If the label does not clearly indicate the amount of trans-resveratrol, then there is no way of knowing its purity content, or if it even has any health benefits. It is important to note that 250-500 mg of trans-resveratrol is the minimum daily amount that is needed to promote the benefits of this product for healthy individuals, (higher dosage may be required for individuals with certain health conditions).

What is “Pure” Resveratrol?

“Pure Resveratrol” refers to a product that should contain contains only TRANS-RESVERATROL, the active ingredient and the beneficial substance in resveratrol. It is important to note that pure trans resveratrol does not cause any side effects compared to low purity products which contain emodin and other substances (part of the plant)  that may cause gastrointestinal problems in sensitive individuals. As a reference, the physical appearance resveratrol made of Japanese-knotweed varies according to its purity and therefore may help distinguish between a high purity and low purity product.  Pure resveratrol is white/off-white in color, and is odorless, while low purity resveratrol is brown and has a distinctive odor.  The higher the purity is, the brighter the color will be.  Resveratrol obtained from grapes is very expensive to produce and therefore is only available in low purity of 5-8 percent (trans-resveratrol content).

Trans-Resveratrol Vs Cis-Resveratrol

Both trans-resveratrol and CIS-resveratrol are found naturally in grapes, Japanese knotweed and other plants, however Trans-Resveratrol is the beneficial health substance in resveratrol products, while CIS form has no health benefits. High purity resveratrol contains high amount of trans-resveratrol, while lower purity products contain higher amount of CIS-resveratrol and lower amounts of trans-resveratrol.
Due to the  purifying process low purity resveratrol cost about 40-60% less than pure trans-resveratrol. 

Resveratrol 99% Vs Resveratrol 50%

Resveratrol-99 contains 99 percent of pure trans-resveratrol, the beneficial substance of resveratrol, while resveratrol-50 contains only 50 percent of trans-resveratrol. The other 50 percent contain ingredients that are a natural part of the plant but which have no health benefits. These ingredients include CIS-resveratrol and emodin, which may act as a laxative in some sensitive individuals. These ingredients account for the darker color and stronger odor of resveratrol- 50, as compared to resveratrol-99, which is white, has no odor, and has no side effects. Due to the purification process, resveratrol 50% typically costs about 40-50 percent less than resveratrol 99%.

99% Purity Capsules

99% Purity Capsules

50% Purity Capsules

50% Purity Capsules



Grape Resveratrol Vs. Japanese Knotweed Resveratrol

Most resveratrol sold in the USA and abroad is made of Japanese Knotweed.  Resveratrol made of grapes is NOT superior to resveratrol made of Japanese knotweed, this is just a myth.  Grapes resveratrol is only available in purities of up to  5%-8% trans-resveratrol compared to knotweed which is available in up to 99%-100% purity. Pure trans-resveratrol (99%) made of knotweed does not contain emodin and does not cause any side effects. Why the difference in purities?  Its all in the cost.  Unlike grapes, knotweed grows in the wild and contains higher concentration of trans-resveratrol.  Prior to processing, knotweed can be stored in room temperature, while grapes need to be kept frozen. It takes about 250 kilograms of grape skins to produce 1 kilogram of resveratrol that yields only 5% trans-resveratrol product.

Beware of products that are labeled “made with grape resveratrol”. Most of those products are worthless. Usually, a minuscule amount (a few milligrams) of lowest purity grape resveratrol is added to a low purity knotweed resveratrol, a product which is low in price but also in effectiveness.  Again, it’s another marketing gimmick to intentionally mislead consumers for the sole purpose of monetary gain while the product has no health benefit. Another product that may be confused with grape resveratrol (or resveratrol), is grape-seed, which does not contain resveratrol.

It’s clear that the source of resveratrol is not what matters, what is important is knowing the purity of the product you are purchasing. Remember, it’s the amount of trans-resveratrol that counts, not the source of the product.

Micronized Resveratrol

Micronization is a process of reducing the size of a solid material. Some dietary supplements are water-soluble and therefore their absorption rate in the body is higher than the non water-soluble supplements. Since resveratrol is non water-soluble, the only way to increase its absorption and bio-availability rate is to reduce the size of the particle. The smaller the particle size the higher the absorption rate. Mega Resveratrol’s average particle size is 3 µm (0.003 mm), compared to 170 to 220 µm (0.17-0.22 mm) of standard resveratrol. Clinical studies have shown that micronized particle size increases the absorption rate by up to 210%.

Safety and Dosage

Resveratrol has been used for many years and no safety issues have ever been reported. During the last few years, a number of clinical studies confirmed that taking pure trans-resveratrol in dosages of up to 6,000 mg daily is safe and does not cause any side effects.  Unlike pure trans-resveratrol, lower purity resveratrol may cause gastrointestinal side effects due to the content of emodin which may act as a laxative in sensitive individuals.  Mega Resveratrol contains no emodin.

As a reference, the dosage used in the “Harvard Study” was equal to 23 mg per kg or about 500 mg per 50 pounds of body weight. For example: A person that weighs 150 pounds would take 1500 mg daily. This is just a suggestion based on the “Harvard Study”, not a rule.

Resveratrol may enhance the effect of blood thinning medications (i.e. Coumadin, Aspirin, etc.) and increase the risk of bleeding. Consult your health-care provider before taking resveratrol. Individuals with allergic reaction to grapes, red wine or polyphenols, are advised not to consume resveratrol.

Resveratrol Studies (Resveratrol Health Benefits)


Atherosclerosis (Hardening of the arteries)


Joint disease





Macular Degeneration

Lyme disease


Neurodegenerative diseases


Multiple sclerosis

Cell damage

Calorie restriction mimetic

Harvard Study-(PDF file)


About Mega Resveratrol 99% Trans-Resveratrol

Mega Resveratrol 99 is a pharmaceutical-grade supplement, micronized and purified to a minimum of 99% pure trans-resveratrol.

MegaResveratrol.com was a pioneer in introducing high potency resveratrol products and in setting the standards of voluntary third party independent lab testing for purity and safety.

We offer premium grade natural resveratrol supplements delivered in a vegetarian capsule and in powdered form at an economical price.

At Mega Resveratrol we are always trying to improve our products. For example, most dietary supplements and vitamins are made with “inactive ingredients”. These ingredients are added mainly to facilitate the manufacturing process but they have no health benefits. In some cases, these added ingredients may produce an allergic reaction or they even are unsafe.  All of our resveratrol products are made with no excipient ingredients added. That means vegetarian capsules that contain pure resveratrol with absolutely no additives, binders, fillers or preservatives. (i.e. stearate acid, silica dioxide, etc.), just pure resveratrol.

Our natural resveratrol products are encapsulated in the USA in a GMP facility regulated by the FDA. Every batch is tested for purity by an independent U.S. laboratory. Please refer to the Certification Page.

Mega Resveratrol is a proud supplier of pure trans-resveratrol products to pharmacies and research institutions in USA and abroad.  See the About Us page for details. Our customer’s reviews are independently posted and may be viewed at Google Reviews Page.

President’s letter:

April, 2013

There is a difference between our company and most other companies and it’s not only in the quality of the product. It’s in the story behind the company and its foundation.

In 2003 I was lucky enough to walk out of a hospital alive after surviving a heart attack. I felt like a helpless “walking time bomb.” I knew it wasn’t a question of “if” but “when” my next heart attack would happen. I thought I had two choices – I could rely on miracles or on doctors and statins. Neither one prevented my first heart attack.

For two years I searched for something better than statins or aspirin. I was looking for a natural product that would keep my blood flowing, regardless of my cholesterol levels.

I tried different products and in 2005 I found resveratrol. Back then, the maximum purity available was only 20%. That meant that only 20% of each capsule’s contained beneficial trans-resveratrol, the rest was fillers and impurities. With such low purity levels, to achieve a dosage of 1,000 mg of trans-resveratrol I had to take 20-30 capsules daily.

As you can imagine, I was looking for a highly pure resveratrol product. With my business background, I knew I could produce it and in 2007 we started manufacturing 99% pure trans-resveratrol capsules. I founded Mega Resveratrol because I couldn’t resist offering the same high quality product I wanted for myself to other people. Mega Resveratrol is nothing less than what I would take myself.

That same year I had a routine “stress test” at the hospital. The cardiologist couldn’t understand how and why I performed so well until I described my use of resveratrol.

It’s been almost ten years since my heart attack, and I’ve never felt better. My cardiologist now takes resveratrol, and my company provides high quality resveratrol to satisfied consumers, health-care providers and research institutes in the USA and abroad.

As the owner/founder of Mega Resveratrol, I will never reduce the quality of my product in exchange for monetary gain. I will never sell a product that is less than what I personally use. That is my promise and guarantee!!!

D. Efrat, President

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Heart-Disease (Cardiovascular)
Memory Problems
Acid Reflux (GERD)
Liver Problems

If you are over the age of 50, you belong to an age group that is likely to be coping with one or more health conditions. Most of the health conditions listed below can be significantly improved by adding effective dietary supplements to your regimen and by making slight changes to your lifestyle, diet, and exercise.

In some cases, natural dietary supplements may be a better alternative to prescription or over-the-counter medications. Adverse effects of certain prescription medications, such as statins, may cause serious complications that include damage to the liver and elevated blood sugar, leading to diabetes, damage to the brain and memory, and much more [¹]. Unfortunately, most people do not even know what these side effects are and the serious damage they can cause [²]. The recommended supplements below are shown to be effective, as evidenced by numerous scientific studies and by high ratings posted by real users. Additionally, these supplements tend to be much safer overall than prescription drugs, as most of them do not have any known side effects when taken at the right dosage. 

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Cardiovascular Health
For many years, we were led to believe that cholesterol is our biggest enemy, and that is why those of us with high cholesterol levels are instantly prescribed statins by most doctors. Other cardiologists argue that high cholesterol levels are not necessarily the cause of heart disease [³], but rather the type of cholesterol, or more accurately the particle-size [4] of LDL cholesterol, that may cause the problem. They claim that individuals with small LDL particles are more likely to suffer a heart attack than those with large-sized particles, regardless of their cholesterol level. Small particles tend to clog the arteries and cause heart attack while large particles do not. There are two blood tests for cholesterol particle size: VAP and LPP, which are widely available, but unfortunately are not widely offered by physicians. Instead, they rush to prescribe statins (along with the horrible side effects) to anyone with high cholesterol. Some doctors even claim that low levels of cholesterol may cause damage to the body, brain, and memory and can even lead to Alzheimer’s disease.

It is therefore not surprising, according to numerous cardiologists, that about 50 percent of their patients who suffered from a heart attack had low cholesterol levels [5]. Most of these individuals were fit–they exercised daily, followed a healthy diet–yet, they ended up in the emergency room. This suggests that cholesterol level is not necessarily the main factor contributing to heart attacks. Other than LDL particle-size, there are other conditions that may cause a heart attack, including high blood pressure, stress, and even one “bad” meal can cause inflammation and increase the risk of a spontaneous heart-attack.

Changes in diet alone can bring positive results. However, we first need to find the “miracle diet” that works. This may be almost impossible when doctors continue to give us conflicting advice that so far has not shown an overall reduction in the number of heart attacks in the U.S. We are told to cut down on saturated fats, while studies show that diets high in carbohydrates, sugars, and trans-fats are the main cause of heart disease.

I am neither a physician nor an expert on heart disease, but the fact is that even doctors do not have the definite answer to this problem, which according to the CDC is the leading cause of death in the U.S. The argument about the cause and the treatment of heart disease is still ongoing, while heart attacks are on the rise.

Heart attacks, unlike other diseases, do not warn us prior to an attack.  Healthy individuals should not wait for a bad cardiovascular event to happen.  We can do something today to prevent it.  Changing our diet and exercising may be good ideas but may not be enough.

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Aside from resveratrol, other effective dietary supplements may protect the heart, including CoQ10, Omega-3, and Nattokinase.  CoQ10 is used to treat blood vessels, condition the heart, and is specifically important for individuals who use statins.  The preferred and more effective form of CoQ10 is Ubiquinol.  Omega-3 (with a minimum 500 mg of combined EPA and DHA) and Nattokinase, which is used to lower blood pressure.

 If you are on a statins regimen or any other prescription medication, do not stop taking your medication as prescribed without consulting your healthcare provider, but at the same time, you should be aware of potential side effects.

Recommended Dietary Supplements – Cardiovascular:
CoQ10 – Ubiquinol – Brand: Jarrow Formula, 100 mg (2 capsules daily). 

Omega-3 Fish Oil – Brand: Carlson Laboratories – (Price Option 1), 1250 mg (1-2 capsules daily). 

Omega-3 Fish Oil – Brand: Carlson Laboratories – (Price Option 2), 1250 mg (1-2 capsules daily). 

Resveratrol – Pure Trans-Resveratrol, 500-1000 mg (1-2 capsules daily).  

Resveratrol is not likely to reduce blood sugar significantly; however, diabetics are prone to developing other complications such as heart, kidney, feet, eye, nerve, joint, and bone problems. Consuming resveratrol is essential as a prevention and protection against further complications. Other dietary supplements that have proven effective in various studies to lower blood sugar are listed below.  Blood sugar can be significantly lowered by following a diet low in carbohydrates (low or no bread, pasta, potato etc.).

Recommended Dietary Supplements – Diabetes:
Alpha Lipiod Acid (ALA) – Brand: BRI Nutrition, 300 mg softgel (2 capsules, 1-2 times daily). 
Alpha Lipoic Acid (Sustain) – Brand: Jarrow Formulas, 300 mg (2 capsules, 1-2 times daily). 

Magnesium Taurate – Brand: Cardiovascular Research, 125 mg (1 capsule daily). 

Chromium Picolinate – Brand: Solgar, 500 mcg (1 capsule, 2 times daily). 

Vanadyl Sulfate – Brand: Olympian Labs, 20 mg (1-2 capsules, 1-2 times daily – take with food).  

Gymnema – Brand: Nature’s Way, 500 mg (1 capsule, 2 times daily). 

Beta Glucan – Brand: Jarrow Formulas, 250 mg (1 capsule, 2 times daily). 

Resveratrol – Pure Trans-Resveratrol, (500-1000 mg, 2 times daily, or 500 mg per 50 lbs. of body weight).  

Aging, alcohol, prescription medications, and lack of sleep are only a few reasons that cause damage to the brain.  At a certain age, many of us become a little forgetful; we forget names, words, etc.  It is quite frustrating and embarrassing when we forget a word or someone’s name in the middle of a conversation.  Lowering consumption of alcohol and taking fewer medications can improve the condition but may not be enough.  Below are specific dietary supplements to improve memory found to be effective in various studies.  Some of these supplements are being used as part of Alzheimer’s treatment.

Recommended Dietary Supplements – Memory:
Vinpocetine – Brand: Jarrow Formulas, 5 mg (1 capsule, 1-2 time daily).  

Phosphatidylserine (PS) – Brand: Jarrow Formulas, 100 mg (1 capsules, 1-3 times daily).  

5-HTP – Brand: Jarrow Formulas, 100 mg (1 capsule daily).  

Curcumin 95 – Brand: Jarrow Formulas, 500 mg (1-2 capsules daily). 
Choline – Brand: Jarrow Formulas, 250 mg (1 capsule, 1-2 times daily).  
Resveratrol – Pure Trans-Resveratrol, (250-500 mg, 1-2 times daily, or 500 mg per 50 lbs. body weight).  

Pramiracetam 98%:  Pramiracetam is the only product on this list which is not a natural dietary supplement.  Pramiracetam is a synthetic product but very effective in memory treatment (and low in side effects).

Recommended dosage: 300 mg (1 capsule, 1-2 times daily).  Available from various vendors.  Please search online for term “Pramiracetam.” (When consuming Pramiracetam, choline should be used in conjunction).

Many factors can cause liver damage.  Again, alcohol and medications are just two of them.  Many people do not have any symptoms until a serious problem suddenly appears.  A routine blood test to monitor and diagnose liver condition is widely available.  Individuals who consume alcohol, use prescription or over-the-counter medications, or suffer from elevated AST and ALT can protect their livers by consuming a dietary supplement that works like a miracle.  It is called milk thistle.

Recommended Dietary Supplements – Liver: 

Milk Thistle – Brand: Jarrow Formulas, 150 mg (1-4 capsules, 1-2 times daily).  

Please Note:  milk thistle supplements should contain a minimum of 80% Silymarin.

Acid-Reflux (GERD)
Acid reflux is not only an annoying and painful condition, but if left untreated over time, may lead to serious complications.  There are various reasons leading to acid-reflux; an endoscopy test is available to aid in diagnosis.  There are many prescriptions and over-the-counter medications, but most just make you feel better by treating the symptoms, not the cause.  Due to damage from side effects, most are not recommended as a long-term regimen.  Various dietary supplements claim to improve the condition, but most of them do not treat the cause.  One dietary supplement is effective in most individuals, depending on the root cause of the disease.  About 8 out of 10 individuals rate the product as excellent.  The product is called D-Limonene and is an oil extract made of orange peel.  Based on users’ feedback, this is one product that seems to work well.  One capsule a day should be sufficient, and for most individuals a temporary regimen of one to two capsules a day for 10-20 days usually shows improvement.  In some cases, the problem is eliminated.

Recommended Dietary Supplements – Acid-Reflux:

D- Limonene – Brand: Jarrow Formulas, 1000 mg (1 capsule, 1 to 2 times daily) for 10-20 days. (After 20 days, keep taking one capsule daily if the symptoms returned). 

Resveratrol acts as an anti-inflammatory and therefore reduces joint inflammation and the pain associated with the disease. Depending on the severity of the problem, resveratrol may reduce inflammation and pain within hours.  For moderate cases of joint-disease, resveratrol may be a better alternative than prescription medications or over-the-counter anti-inflammatory medications that may reduce inflammation but not without serious side effects.  Try resveratrol and find out if it works for you.

Recommended Dietary Supplements – Joints:

This section will be updated soon.

Curcumin 95 – Brand: Jarrow Formulas, 500 mg (1-4 capsules daily). 

Resveratrol – Pure Trans-Resveratrol, (500-1000 mg, 2 times daily or 500 mg per 50 lbs. body weight).  

By D. Efrat, President and founder, MegaResveratrol.net
March 16, 2015 

Legal Disclaimer

The content above is for informational purpose only and is NOT intended as medical advice. By consuming any of the suggested products posted above, you are doing so at your own responsibility and liability.  Megaresveratrol.net, Candlewood Stars Inc, and its employees will not be liable for any damage caused to you by consuming any of the dietary supplements listed above. Do not stop using any medication, and do not consume any dietary supplements without consulting your health care provider.

[1] Statins adverse-Effects- Mayoclinic >>>        FDA Expands Advice On Statin Risks >>>

[2] Dr. Harlan Krumholz – About the use of statins (PBS NewsHour-Video) >>>

[3] Dr. Sinatra: Why your cholesterol can lie >>>

[4] Chris Kresser: why everyone should know their-LDL particle-number >>>      LDL Particle size/number >>>

[5] The Heart Httack Culprit (Dr. Barry Sears) >>>

Chris Kresser: Why your genes aren’t your destiny >>>

Dr. Sinatra (Cardiologist): The Blood lipid ratio to watch, Dr. Sinatra (cardiologist) >>>

Recommended books:
The Great Cholesterol Myth by Jonny Bowden, PhD.  and Stephen Sinatra MD (Amazon books) >>>

30 Days to a Younger Heart with Dr. Steven Masley  (Amazon books) >>>